Factors Involved in Formulation of Oily Delivery System for Proteins Based on PEG-8 Caprylic/Capric Glycerides and Polyglyceryl-6 Dioleate in a Mixture of Oleic Acid with Chitosan
نویسندگان
چکیده
for Proteins Based on PEG-8 Caprylic/Capric Glycerides and Polyglyceryl-6 Dioleate in a Mixture of Oleic Acid with Chitosan Shereen M. Assaf, Nawzat D. Al-Jbour, Ala’a F. Eftaiha, Amani M. Elsayed, Mayyas M. Al-Remawi, Nidal A. Qinna, Babur Chowdhry, Stephen Leharne, and Adnan A. Badwan Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan Suwagh Drug Delivery Systems, Subsidiary of the Jordanian Pharmaceutical Manufacturing Co., Naor, Jordan Department of Chemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia Department of Pharmacology, Faculty of Pharmacy, Petra University, Amman, Jordan School of Science, University of Greenwich, Medway Campus, Kent, UK
منابع مشابه
Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system
The aim of the work reported herein was to study the effect of glucosamine HCl (GlcN·HCl) on the bioactivity (BA) of insulin, administered via subcutaneous (SC) and oral routes, in adult male Sprague Dawley rats. The oral insulin delivery system (insulin-chitosan reverse micelle [IC-RM]) was prepared by solubilizing insulin-chitosan (13 kDa) polyelectrolyte complex in a RM system consisting of ...
متن کاملDesign and Formulation of Optimized Microemulsions for Dermal Delivery of Resveratrol
The objective of this study was to formulate optimal formulations of microemulsions (MEs) and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Oil-in-water MEs were formulated using surfactant (S) PEG-8 caprylic/capric glycerides and cosurfactant (CoS) polyglyceryl-6-isostearate. Ethyl oleate was used as an oily phase. MEs were formulated using 5 : 1, 6 : 1, and 7...
متن کاملFormulation of Propolis Phenolic Acids Containing Microemulsions and Their Biopharmaceutical Characterization
Microemulsions (MEs) were formulated using PEG-8 caprylic/capric glycerides and ethanolic propolis extracts. Characterization of MEs was performed by determining mean droplet size, polydispersity index, stability under varying external factors, and formulation effect on delivery of phenolic compounds into the skin ex vivo. Essential oils were included into the formulations of MEs and their infl...
متن کاملFormulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib.
Celecoxib is a hydrophobic and highly permeable drug belonging to class II of biopharmaceutics classification system. Low aqueous solubility of celecoxib leads to high variability in absorption after oral administration. Cohesiveness, low bulk density and compressibility, and poor flow properties of celecoxib impart complications in it's processing into solid dosage forms. To improve the solubi...
متن کاملStudies on the formation of O/W nano-emulsions, by low-energy emulsification method, suitable for cosmeceutical applications.
The formation of oil/water (O/W) nano-emulsions suitable for cosmeceutical application was studied. Nano-emulsions were prepared by using phase inversion composition (PIC) method, one of the low-energy emulsification methods. The process consist of stepwise water addition to oil/surfactant mixture, at T = 25°C. Caprylic/capric triglycerides (GTCC), propylene glycol dicaprylate/dicaprate (PC) an...
متن کامل